In collaboration with the Alzheimer's Disease Research Center, the Mayo Clinic Study of Aging aims to address these gaps in the understanding of aging, dementia and Alzheimer's disease. However, researchers have limited information on how frequently biomarkers occur in middle-aged and older adult populations, and on how effectively biomarkers can predict cognitive outcomes. In this article, the gerontological factors affecting the successful aging of the elderly have been uncovered, the quality of life and successful aging issues. Guidelines from the National Institute on Aging and the Alzheimer's Association on characterizing the preclinical and mild cognitive impairment stages of Alzheimer's disease place a major emphasis on developing and using biomarkers. The brain changes underlying dementia and Alzheimer's disease precede clinical cognitive changes by 10 to 20 years - providing a window of opportunity to prevent the disease. Alzheimers Disease and Non-Demented High Pathology Control Nonagenarians: Comparing and Contrasting the Biochemistry of Cognitively Successful Aging. Addressing unmet needs in aging and dementia careĪ major challenge in the field of aging and dementia is the inability to identify the people who will develop dementia and, in particular, Alzheimer's disease, before they develop symptoms. The long-term goals of the Mayo Clinic Study of Aging are to develop tools to predict and prevent cognitive decline and dementia, develop risk-prediction models for cognitive impairment, and conduct aging-related research to promote successful aging. Assessment of cognition and respiratory function in oral verbal tasks: A life-span study with healthy individuals from adolescence to late adulthood.The Mayo Clinic Study of Aging provides resources to help older adults make choices and habits for optimal physical, cognitive and emotional health.Psychomotor decline of speech production in Alzheimer’s disease and normal aging and the ir association with myelin degeneration.Age-related changes in dexterity and cognition in normal aging.Interplay of cognition and gait in normal and pathological aging.The infrastructure of the gerontolaboratory comprises equipment and materials to conduct neuropsychological testing, 3D motion capture techniques, advanced research audiometry, spatio-temporal gait analysis, eye-tracking, spectrogram and modern pneumotacographs for speech analysis. We furthermore collaborate with the University Hospital of North Norway to perform brain imaging (MRI).īelow you find more detailed information about our most central projects. To diagnose Alzheimers disease (AD) early, tests sensitive to neuropathology and insensitive to normal ageing are of greatest benefit. We employ a wide range of methods to analyze cognitive abilities, behavior, audition, motor and respiratory functions. Although, we have a special focus on adult development and aging (individuals over 60 years of age), our pool of participants also includes younger populations from late adolescence and beyond. Normal and pathological conditions are studied, which includes successful aging, typical aging, mild cognitive impairment and early Alzheimer’s disease. Our team works to understand the psychological and biological processes that influence cognitive and motor decline in late adulthood through a behavioral and clinical neuroscientific approach.
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